The networking equipment maker said the impending cuts will save the company about $1.3 billion in restruturing charges over several quarters. Some 2,100 employees will be leaving the company on a voluntary early-retirement programme, while the remaining 4,400 employees would be laid off.
It also said it will sell a Mexican subsidiary to Foxconn Technology Group.
According to a report by the BBC, Cisco is facing increased competition, and said it needs to overhaul the way it operates and focus on core businesses.
Chief executive officer John Chambers said earlier this year that Cisco would look to exit non-performing or less profitable businesses, and refocus on its core networking operations.
Analysts have complained that the company expanded into too many areas at the expense of its main markets.
In May, Mr Chambers announced his intention to shut Cisco's Flip video camera unit resulting in 550 job losses.